Synthesis of 3',4'-dideoxy and 3',4',5''-trideoxyribostamycin active against kanamycin-resistant E. coli and P. aeruginosa.

cin B2) and S'^-dideoxyneamine^ have confirmed that removal of the hydroxyl group which is phosphorylated by drug-resistant bacteria from kanamycins gives compounds active against the resistant organisms. As an extension of this work, we describe in this paper the syntheses of two deoxy-derivatives of ribostamycin4). If inactivation of ribostamycin by Escherichia coli K12-ML 1629 and K12-ML 1630 carrying R factor (see Table 1) is caused by phosphorylation